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Cleaved-MPO 89k (A49) rabbit pAb

CAT: 0855-ES1070-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES1070-01Size:50 µL
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Background
Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of neutrophils. [provided by RefSeq, Nov 2014]
Description
Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of neutrophils. [provided by RefSeq, Nov 2014],
Product Name Alternative
MPO; Myeloperoxidase; MPO
UniProt
P05164
Swiss Prot
P05164
Reactivity
Human; Rat; Mouse
Immunogen
Synthesized peptide derived from Cleaved-MPO 89k (A49) . at AA range: 40-120
Target
MPO
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
89kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
89kD
Fragment
IgG
Subcellular Location
Lysosome.
Other Product Names
MPO; Myeloperoxidase; MPO
Gene ID (Human)
4353

UniProtKB · P05164

Myeloperoxidase

PERM_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P05164
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
MPO
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
MPO
EC number
1.11.2.2
Processing
Precursor
Secondary accessions
A1L4B8, Q14862, Q4PJH5, Q9UCL7
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

CalciumHemeIronMetal-binding

Cellular component

ChromosomeCytoplasmic vesicleLysosomeNucleusSecreted

Disease

Disease variant

PTM

Disulfide bondGlycoproteinOxidation

Biological process

Hydrogen peroxide

Molecular function

OxidoreductasePeroxidase

Domain

Signal

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