CFAD (Cleaved-Ile26) rabbit pAb
CAT:
855-ES19983-02
Size:
100 μL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
CFAD (Cleaved-Ile26) rabbit pAb
- Description: Catalytic activity: Selective cleavage of Arg-|-Lys bond in complement factor B when in complex with complement subcomponent C3b or with cobra venom factor. Disease: Defects in CFD are the cause of complement factor D deficiency [MIM: 134350]. This deficiency predisposes to invasive meningococcal disease. function: Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway. online information: CFD mutation db, similarity: Belongs to the peptidase S1 family. similarity: Contains 1 peptidase S1 domain.
- Synonyms: Complement factor D (EC 3.4.21.46;Adipsin;C3 convertase activator;Properdin factor D)
- Gene ID: 1675
- UniProt: P00746
- Cellular Locus: Secreted.
- Host: Rabbit
- Species Reactivity: Human, Rat, Mouse,
- Immunogen: Synthesized peptide derived from human CFAD (Cleaved-Ile26)
- Clonality: Polyclonal
- Validated Applications: WB, ELISA
- Stability: 1 year
- Concentration: 1 mg/mL
- Dilution: WB 1:1000-2000 ELISA 1:5000-20000
- Molecular Weight: 25kD
- Storage Conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.