Cleaved-KLK11 (I54) rabbit pAb

• Background:

  Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing of this gene results in multiple transcript variants encoding distinct isoforms which are differentially expressed.[provided by RefSeq, Nov 2009]

• Description:

  Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing of this gene results in multiple transcript variants encoding distinct isoforms which are differentially expressed. [provided by RefSeq, Nov 2009],

• Synonyms:

  KLK11; PRSS20; TLSP; Kallikrein-11; hK11; Hippostasin; Serine protease 20; Trypsin-like protease

• Gene ID:

  11012

• UniProt:

  Q9UBX7

• Cellular Locus:

  [Isoform 1]: Secreted.; [Isoform 2]: Golgi apparatus.

• Host:

  Rabbit

• Species Reactivity:

  Human, Rat, Mouse,

• Reactivity:

  Human; Rat; Mouse

• Immunogen:

  The antiserum was produced against synthesized peptide derived from human Kallikrein-11. AA range:35-84

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Source:

  Rabbit

• Applications:

  WB, ELISA

• Validated Applications:

  WB, ELISA

• Stability:

  -20°C/1 year

• Concentration:

  1 mg/mL

• Dilution:

  Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.

• Molecular Weight:

  25kD

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

• Observed Molecular Weight:

  25 kD

• Subcellular Location:

  [Isoform 1]: Secreted.; [Isoform 2]: Golgi apparatus.

• Other Product Names:

  KLK11; PRSS20; TLSP; Kallikrein-11; hK11; Hippostasin; Serine protease 20; Trypsin-like protease

• Gene ID (Human):

  11012

• SwissProt (Human):

  Q9UBX7