MLKL (8H7) Mouse mAb

• Background:

  Mixed lineage kinase domain-like protein (MLKL) is a pseudokinase that was identified as downstream target of RIP3 in the necroptosis pathway. During necroptosis RIP3 is phosphorylated at Ser227, which recruits MLKL and leads to its phosphorylation at Thr357 and Ser358.

• Description:

  Mixed lineage kinase domain-like protein (MLKL) is a pseudokinase that was identified as downstream target of RIP3 in the necroptosis pathway. During necroptosis RIP3 is phosphorylated at Ser227, which recruits MLKL and leads to its phosphorylation at Thr357 and Ser358.

• Synonyms:

  Mixed lineage kinase domain like protein, FLJ34389

• Gene ID:

  197259

• UniProt:

  Q8NB16

• Cellular Locus:

  Cell membrane, Cytoplasm, Membrane

• Host:

  Mouse

• Species Reactivity:

  Human

• Reactivity:

  Human

• Immunogen:

  Synthetic Peptide

• Clonality:

  Monoclonal

• Isotype:

  IgG1

• Source:

  Mouse

• Applications:

  IHC

• Validated Applications:

  IHC

• Stability:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

• Concentration:

  1 mg/mL

• Dilution:

  IHC 1:100-200

• Molecular Weight:

  54kDa

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

• Observed Molecular Weight:

  54 kDa

• Subcellular Location:

  Cell membrane, Cytoplasm, Membrane

• Other Product Names:

  Mixed lineage kinase domain like protein, FLJ34389

• Gene ID (Human):

  197259

• SwissProt (Human):

  Q8NB16