MLKL (phospho Ser358) rabbit pAb

MLKL (phospho Ser358) rabbit pAb

• Description: This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015],
• Synonyms: Mixed lineage kinase domain-like protein
• Gene ID: 197259
• UniProt: Q8NB16
• Cellular Locus: Cytoplasm. Cell membrane. Nucleus. Localizes to the cytoplasm and translocates to the plasma membrane on necroptosis induction (PubMed:24316671). Localizes to the nucleus in response to orthomyxoviruses infection (By similarity)..
• Host: Rabbit
• Species Reactivity: Human
• Immunogen: Synthesized peptide derived from human MLKL (phospho S358)
• Clonality: Polyclonal
• Validated Applications: IHC, IF, WB
• Stability: 1 year
• Concentration: 1 mg/mL
• Dilution: IHC-p 1:100-500;IF/ICC 1:100-500;WB 1:500-2000
• Molecular Weight: 55kD
• Storage Conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.