Sinigrin (hydrate)

• Description:

  Sinigrin (Allyl-glucosinolate) hydrate is an orally active glucosinolate found in cruciferous plants. Sinigrin hydrate possesses multiple activities such as anti-cancer, antibacterial, antifungal, anti-inflammatory, antioxidant, and inhibition of fat synthesis. Sinigrin hydrate can be used in the research of tumors, inflammatory, and metabolic diseases[1][2][3][4].

• Product Name Alternative:

  Allyl-glucosinolate (hydrate) ; 2-Propenyl-glucosinolate (hydrate)

• UNSPSC:

  12352005

• Target:

  Akt; AMPK; Apoptosis; Bacterial; CDK; Fungal; Interleukin Related; mTOR; p38 MAPK; PI3K; PPAR; Reactive Oxygen Species (ROS)

• Type:

  Natural Products

• Related Pathways:

  Anti-infection; Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR; Vitamin D Related/Nuclear Receptor

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cancer; Infection; Metabolic Disease; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/sinigrin-hydrate.html

• Purity:

  99.92

• Solubility:

  H2O : ≥ 50 mg/mL

• Smiles:

  O[C@@H]1[C@@H](O)[C@H](S/C(CC=C)=N/OS(=O)(O[K])=O)O[C@H](CO)[C@H]1O.O

• Molecular Formula:

  C10H18KNO10S2

• Molecular Weight:

  415.48

• References & Citations:

  [1]Mazumder A, et, al. Sinigrin and Its Therapeutic Benefits. Molecules. 2016 Mar 29;21 (4) :416.|[2]Lee HW, et al. Inhibitory effect of sinigrin on adipocyte differentiation in 3T3-L1 cells: Involvement of AMPK and MAPK pathways. Biomed Pharmacother. 2018 Jun;102:670-680.|[3]Li S, et al. Sinigrin Impedes the Breast Cancer Cell Growth through the Inhibition of PI3K/AKT/mTOR Phosphorylation-Mediated Cell Cycle Arrest. J Environ Pathol Toxicol Oncol. 2022;41 (3) :33-43.|[4]Rama Satya Sri Kotipalli, et al. Sinigrin Attenuates the Dextran Sulfate Sodium-induced Colitis in Mice by Modulating the MAPK Pathway. Inflammation. 2023 Jun;46 (3) :787-807.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, sealed storage, away from moisture)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• Isoform:

  CDK4; CDK6; IL-1; IL-6; PPARγ

• CAS Number:

  [64550-88-5]