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Sinigrin

CAT: 0804-HY-N0404-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0804-HY-N0404-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Sinigrin (Allyl-glucosinolate) is an orally active glucosinolate found in cruciferous plants. Sinigrin possesses multiple activities such as anti-cancer, antibacterial, antifungal, anti-inflammatory, antioxidant, and inhibition of fat synthesis. Sinigrin can be used in the research of tumors, inflammatory, and metabolic diseases[1][2][3][4].
CAS Number
[3952-98-5]
Product Name Alternative
Allyl-glucosinolate; 2-Propenyl-glucosinolate
UNSPSC
12352005
Hazard Statement
H317
Target
Akt; AMPK; Apoptosis; Bacterial; CDK; Fungal; Interleukin Related; mTOR; p38 MAPK; PI3K; PPAR; Reactive Oxygen Species (ROS)
Type
Natural Products
Related Pathways
Anti-infection; Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR; Vitamin D Related/Nuclear Receptor
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer; Infection; Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/sinigrin.html
Purity
99.97
Solubility
H2O : 25 mg/mL (ultrasonic)
Smiles
O[C@@H]1[C@@H](O)[C@H](S/C(CC=C)=N/OS(=O)(O[K])=O)O[C@H](CO)[C@H]1O
Molecular Formula
C10H16KNO9S2
Molecular Weight
397.46
Precautions
H317
References & Citations
[1]Lee HW, et al. Inhibitory effect of sinigrin on adipocyte differentiation in 3T3-L1 cells: Involvement of AMPK and MAPK pathways. Biomed Pharmacother. 2018 Jun;102:670-680.|[2]Rama Satya Sri Kotipalli, et al. Sinigrin Attenuates the Dextran Sulfate Sodium-induced Colitis in Mice by Modulating the MAPK Pathway. Inflammation. 2023 Jun;46 (3) :787-807. |[3]Li S, et al. Sinigrin Impedes the Breast Cancer Cell Growth through the Inhibition of PI3K/AKT/mTOR Phosphorylation-Mediated Cell Cycle Arrest. J Environ Pathol Toxicol Oncol. 2022;41 (3) :33-43.|[4]Mazumder A, et al. Sinigrin and Its Therapeutic Benefits. Molecules. 2016 Mar 29;21 (4) :416.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
CDK4; CDK6; IL-1; IL-6; PPARγ

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