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CSNK2-IN-1

CAT: 0804-HY-163783Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-163783Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CSNK2-IN-1 is a potent and selective CSNK2 inhibitor with IC50 of 1.7 nM and 0.66 nM for CSNK2A1 and CSNK2A2, respectively. CSNK2-IN-1 has antiviral activity against beta-coronaviruses such as SARS-CoV-2 and MHV. CSNK2-IN-1 has good solubility, metabolic stability, and low cytotoxicity, but its plasma concentration in vivo decreases rapidly and is insufficient to achieve pharmacological effects. CSNK2-IN-1 can be used in the research of antiviral drug development[1].
UNSPSC
12352005
Target
Casein Kinase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Stem Cell/Wnt
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/csnk2-in-1.html
Smiles
N#CC1=C2N=C(C=C(N2N=C1)NC3CC3)NC4=CC=C(C(N5C=NN=C5)=C4)N(CC)CCN
Molecular Formula
C22H25N11
Molecular Weight
443.51
References & Citations
[1]Ong, et al. More than an Amide Bioisostere: Discovery of 1, 2, 4-Triazole-containing Pyrazolo [1, 5-a] pyrimidine Host CSNK2 Inhibitors for Combatting β-Coronavirus Replication. Journal of Medicinal Chemistry (2024) .
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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