CSNK2-IN-1

• UNSPSC Description:

  CSNK2-IN-1 is a potent and selective CSNK2 inhibitor with IC50 of 1.7 nM and 0.66 nM for CSNK2A1 and CSNK2A2, respectively. CSNK2-IN-1 has antiviral activity against beta-coronaviruses such as SARS-CoV-2 and MHV. CSNK2-IN-1 has good solubility, metabolic stability, and low cytotoxicity, but its plasma concentration in vivo decreases rapidly and is insufficient to achieve pharmacological effects. CSNK2-IN-1 can be used in the research of antiviral drug development[1].

• Target Antigen:

  Casein Kinase

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage;Stem Cell/Wnt

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/csnk2-in-1.html

• Smiles:

  N#CC1=C2N=C(C=C(N2N=C1)NC3CC3)NC4=CC=C(C(N5C=NN=C5)=C4)N(CC)CCN

• Molecular Weight:

  443.51

• References & Citations:

  [1]Ong, et al. More than an Amide Bioisostere: Discovery of 1, 2, 4-Triazole-containing Pyrazolo [1, 5-a] pyrimidine Host CSNK2 Inhibitors for Combatting β-Coronavirus Replication. Journal of Medicinal Chemistry (2024).

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported