CSNK2-IN-2

CSNK2-IN-2

• UNSPSC Description: CSNK2-IN-2 (compound 2) is an orally active CSNK2 inhibitor. CSNK2-IN-2 has an IC50 of 29 μM against CLK11. CSNK2-IN-2 has a half-life of 2.5 h and an AUC of 10,100 h × nM. CSNK2-IN-2 can be used in antiviral studies[1].
• Target Antigen: Casein Kinase
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage;Stem Cell/Wnt
• Applications: COVID-19-anti-virus
• Field of Research: Infection
• Assay Protocol: https://www.medchemexpress.com/csnk2-in-2.html
• Smiles: CCC(NC1=CC(NC2=NC3=C(C#N)C=NN3C(NC4CC4)=C2)=C(F)C=C1N5C[C@@H](NC)CCC5)=O
• Molecular Weight: 491.56
• References & Citations: [1]Ong HW, et al. Strategic Fluorination to Achieve a Potent, Selective, Metabolically Stable, and Orally Bioavailable Inhibitor of CSNK2. Molecules. 2024 Sep 2;29(17):4158.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported