Cilengitide (TFA)

• Description:

  Cilengitide is a potent and selective integrin inhibitor for αvβ3 and αvβ5 receptor, with IC50 values of 4 nM and 79 nM, respectively.

• Product Name Alternative:

  EMD 121974 (TFA)

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Autophagy; Integrin

• Type:

  Reference compound

• Related Pathways:

  Autophagy; Cytoskeleton

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/Cilengitide_trifluoroacetate.html

• Concentration:

  10mM

• Purity:

  99.92

• Solubility:

  DMF : 100 mg/mL (ultrasonic) |DMSO : 100 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic)

• Smiles:

  O=C (NCC (N[C@H] (C (N[C@H] (CC1=CC=CC=C1) C (N ([C@H]2C (C) C) C) =O) =O) CC (O) =O) =O) [C@H] (CCCNC (N) =N) NC2=O.FC (F) (C (O) =O) F

• Molecular Formula:

  C29H41F3N8O9

• Molecular Weight:

  702.68

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Hariharan S, et al. Assessment of the biological and pharmacological effects of the alpha nu beta3 and alpha nu beta5 integrinreceptor antagonist, Cilengitide (EMD 121974), in patients with advanced solid tumors. Ann Oncol. 2007 Aug;18 (8) :1400-7.|[2]Kim YH, et al. Combination therapy of cilengitide with belotecan against experimental glioblastoma. Int J Cancer. 2013 Aug 1;133 (3) :749-56.|[3]Ten Hagen TL, et al. The αVβ3/αVβ5 integrin inhibitor cilengitide augments tumor response to melphalan isolated limb perfusion in a sarcoma model. Int J Cancer. 2012 Nov 13.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, sealed storage, away from moisture)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 3

• Citation 01:

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• CAS Number:

  199807-35-7