W146 (TFA)

• Description:

  W146 TFA is a selective antagonist of sphingosine-1-phosphate receptor 1 (S1PR1) with an EC50 value of 398 nM.

• UNSPSC:

  12352005

• Target:

  Apoptosis; LPL Receptor

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; GPCR/G Protein

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Cancer; Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/w146-tfa.html

• Concentration:

  10mM

• Purity:

  98.22

• Solubility:

  DMSO : 20 mg/mL (ultrasonic; adjust pH to 3 with 1 M HCl) |Ethanol : < 1 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  O=C (NC1=CC=CC (CCCCCC) =C1) [C@H] (N) CCP (O) (O) =O.O=C (O) C (F) (F) F

• Molecular Formula:

  C18H28F3N2O6P

• Molecular Weight:

  456.39

• References & Citations:

  [1]M Germana Sanna, et al. Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo. Nat Chem Biol. 2006 Aug;2 (8) :434-41. Epub 2006 Jul 9.|[2]Jingjing Liu, et al. 3-amino-4- (3-hexylphenylamino) -4-oxobutyl phosphonic acid (W146), a Selective Antagonist of Sphingosine-1-phospahte Receptor Subtype 1, Enhances AMD3100-stimulated Mobilization of Hematopoietic Stem Progenitor Cells in Animals. J Biochem Pharmacol Res. 2013 Dec; 1 (4) : 197–203.|[3]Hang Wang, et al. Sphingosine-1-phosphate promotes the proliferation and attenuates apoptosis of Endothelial progenitor cells via S1PR1/S1PR3/PI3K/Akt pathway. Cell Biol Int. 2018 May 23.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture and light)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Citation 01:

  Autophagy. 2025 Apr 10:1-19.|Cancer Commun (Lond) . 2025 Jul 16.|iScience. 2024 Oct 30;27 (12) :111290.|J Nutr Biochem. 2024 Apr:126:109587.|Nat Cell Biol. 2025 Jun;27 (6) :918-930.

• CAS Number:

  909725-62-8