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AHR rabbit pAb

CAT: 0855-ES18432-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES18432-01Size:50 µL
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Background
The protein encoded by this gene is a ligand-activated helix-loop-helix transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons. This receptor has been shown to regulate xenobiotic-metabolizing enzymes such as cytochrome P450. Before ligand binding, the encoded protein is sequestered in the cytoplasm; upon ligand binding, this protein moves to the nucleus and stimulates transcription of target genes. [provided by RefSeq, Sep 2015]
Description
The protein encoded by this gene is a ligand-activated helix-loop-helix transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons. This receptor has been shown to regulate xenobiotic-metabolizing enzymes such as Cytochrome P450. Before ligand binding, the encoded protein is sequestered in the cytoplasm; upon ligand binding, this protein moves to the nucleus and stimulates transcription of target genes. [provided by RefSeq, Sep 2015],
UniProt
P35869
Swiss Prot
P35869
Reactivity
Human; Mouse; Rat; Fish
Immunogen
Synthesized peptide derived from human AHR AA range: 408-458
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IF
Concentration
1 mg/ml
Dilution
WB 1:500-2000; IF/ICC 1:100-500
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Cytoplasm . Nucleus . Initially cytoplasmic; upon binding with ligand and interaction with a HSP90, it translocates to the nucleus. .
Gene ID (Human)
196

UniProtKB · P35869

Aryl hydrocarbon receptor

AHR_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P35869
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
AHR
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
Ah receptor, AhR
EC number
—
Processing
Precursor
Secondary accessions
A4D130, Q13728, Q13803, Q13804
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationADP-ribosylation

Molecular function

ActivatorDNA-bindingReceptorRepressor

Biological process

Biological rhythmsCell cycleTranscriptionTranscription regulation

Cellular component

CytoplasmNucleus

Disease

Disease variantRetinitis pigmentosa

Domain

Repeat

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