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Ac-Lys-AMC

CAT: 0804-HY-128919-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-128919-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ac-Lys-AMC (Hexanamide), also termed MAL, is a fluorescent substrate for histone deacetylase HDACs[1].
CAS Number
156661-42-6
UNSPSC
12352005
Target
HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/ac-lys-amc.html
Concentration
10mM
Purity
98.93
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NC1=CC=C(C(O2)=C1)C(C)=CC2=O)[C@@H](NC(C)=O)CCCCN
Molecular Formula
C18H23N3O4
Molecular Weight
345.39
References & Citations
[1]Heltweg B, et al. Nonisotopic substrate for assaying both human zinc and NAD+-dependent histone deacetylases. Anal Biochem. 2003 Aug 1;319 (1) :42-8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

Ac-Lys-AMC
CAS Number156661-42-6
PubChem CID15816975
IUPAC Name(2S)-2-acetamido-6-amino-N-(4-methyl-2-oxochromen-7-yl)hexanamide
Molecular FormulaC18H23N3O4
Molecular Weight345.4
XLogP0.9
Topological Polar Surface Area111
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count7
Heavy Atom Count25
Formal Charge0
Complexity546
SMILES
CC1=CC(=O)OC2=C1C=CC(=C2)NC(=O)[C@H](CCCCN)NC(=O)C
InChI
InChI=1S/C18H23N3O4/c1-11-9-17(23)25-16-10-13(6-7-14(11)16)21-18(24)15(20-12(2)22)5-3-4-8-19/h6-7,9-10,15H,3-5,8,19H2,1-2H3,(H,20,22)(H,21,24)/t15-/m0/s1
InChIKey
NBOQAQRQQNJREL-HNNXBMFYSA-N
Chemical Structure
2D Structure
2D structure of Ac-Lys-AMC
CAS: 156661-42-6
CID: 15816975
Formula: C18H23N3O4
MW: 345.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight345.4
XLogP30.9
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count7
Exact Mass345.16885622
Monoisotopic Mass345.16885622
Topological Polar Surface Area111 Ų
Heavy Atom Count25
Formal Charge0
Complexity546
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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