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(R) -NX-2127

CAT: 0804-HY-153220A-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-153220A-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(R) -NX-2127 ((R) -Compound 28) is an isomer of the BTK PROTAC degrader NX-2127. (Pink: BTK ligand 10 (HY-168302) ; Black: (S) -4- (1- (Pyrrolidin-3-ylmethyl) piperidin-4-yl) aniline (HY-168303) ; Blue: Thalidomide 5-fluoride (HY-W087383).
CAS Number
3024312-52-2
UNSPSC
12352005
Target
Btk; PROTACs
Type
Reference compound
Related Pathways
PROTAC; Protein Tyrosine Kinase/RTK
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/r-nx-2127.html
Purity
98.93
Solubility
10 mM in DMSO
Smiles
O=C1C2=CC(N3C[C@@H](CN4CCC(C5=CC=C(C=C5)NC6=C(N=CC(N7CCCCC7)=N6)C(N)=O)CC4)CC3)=CC=C2C(N1C8C(NC(CC8)=O)=O)=O
Molecular Formula
C39H45N9O5
Molecular Weight
719.83
References & Citations
[1]Robbins DW, et al. Discovery and Preclinical Pharmacology of NX-2127, an Orally Bioavailable Degrader of Bruton's Tyrosine Kinase with Immunomodulatory Activity for the Treatment of Patients with B Cell Malignancies. J Med Chem. 2024 Feb 22;67 (4) :2321-2336.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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