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NX-5948

CAT: 0013-GTR19220598-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19220598-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NX-5948 is a brain-penetrant, orally available PROTAC degrader that targets Bruton's tyrosine kinase (BTK) for cereblon-mediated degradation. This molecule demonstrates anti-inflammatory and anti-tumor activity by inhibiting B-cell activation, supporting research in autoimmune diseases and B-cell malignancies in both cellular and animal models.
CAS Number
2649400-34-8
Product Name Alternative
BTK-IN-24, NX5948
Field of Research
Cardiovascular Research, Pharmacology & Drug Discovery, Signal Transduction
Purity
98.29% (May vary between batches)
Solubility
DMSO:40 mg/mL (49.57 mM) ;10% DMSO+40% PEG300+5% Tween-80+45% Saline:3.3 mg/mL (4.09 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble)
Smiles
N (C=1N=C (C=NC1C (N) =O) N2C[C@@H] (CCC2) N3C (=O) N (C) CC3) C4=CC=C (C=C4) C5CCN (CC6CCN (CC6) C=7C=CC (C (N[C@@H]8C (=O) NC (=O) CC8) =O) =NC7) CC5
Molecular Formula
C42H54N12O5
Molecular Weight
806.96
Storage Conditions
-20°C
Notes
For research use only.

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Alternative Products

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T75124-01NX-5948
A23941-10NX-5948 (BTK-IN-24) 10mg
A23941-5NX-5948 (BTK-IN-24) 5mg
A23941-50NX-5948 (BTK-IN-24) 50mg
A23941-1NX-5948 (BTK-IN-24) 1mg
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