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D-Mannose

CAT: 0804-HY-N0379-02Size: 10 mM - 1 mLDry Ice: NoHazardous: No
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CAT#:0804-HY-N0379-02Size:10 mM - 1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
D-Mannose is a C-2 superpolymer of glucose that occurs naturally in many plants and fruits. D-Mannose has anti-inflammatory and antitumor activity. D-Mannose plays an important role in immune regulation[1][2][3].
CAS Number
3458-28-4
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Endogenous Metabolite
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Others; Cancer
Assay Protocol
https://www.medchemexpress.com/D-Mannose.html
Purity
98.5
Solubility
DMSO : 50 mg/mL (ultrasonic) |H2O : ≥ 50 mg/mL
Smiles
OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)C=O
Molecular Formula
C6H12O6
Molecular Weight
180.16
Precautions
H302, H315, H319, H335
References & Citations
[1]Torretta S, et al. D-mannose suppresses macrophage IL-1β production. Nat Commun. 2020 Dec 11;11 (1) :6343.|[2]Zhang D, et al. D-mannose induces regulatory T cells and suppresses immunopathology. Nat Med. 2017 Sep;23 (9) :1036-1045.|[3]Liu H, et al. D-mannose attenuates bone loss in mice via Treg cell proliferation and gut microbiota-dependent anti-inflammatory effects. Ther Adv Chronic Dis. 2020 Apr 17;11:2040622320912661.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Natural Products
Clinical Information
Phase 4
Isoform
Human Endogenous Metabolite

Chemical Information

Demannose

Aldehydo-D-mannose is the D-enantiomer of aldehydo-mannose. It is a D-mannose and an aldehydo-mannose. It is an enantiomer of an aldehydo-L-mannose.

CAS Number3458-28-4
PubChem CID161658
IUPAC Name(2S,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanal
Molecular FormulaC6H12O6
Molecular Weight180.16
XLogP-2.9
Topological Polar Surface Area118
Hydrogen Bond Donor Count5
Hydrogen Bond Acceptor Count6
Rotatable Bond Count5
Heavy Atom Count12
Formal Charge0
Complexity138
SMILES
C([C@H]([C@H]([C@@H]([C@@H](C=O)O)O)O)O)O
InChI
InChI=1S/C6H12O6/c7-1-3(9)5(11)6(12)4(10)2-8/h1,3-6,8-12H,2H2/t3-,4-,5-,6-/m1/s1
InChIKey
GZCGUPFRVQAUEE-KVTDHHQDSA-N
Chemical Structure
2D Structure
2D structure of Demannose
CAS: 3458-28-4
CID: 161658
Formula: C6H12O6
MW: 180.16
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight180.16
XLogP3-2.9
Hydrogen Bond Donor Count5
Hydrogen Bond Acceptor Count6
Rotatable Bond Count5
Exact Mass180.06338810
Monoisotopic Mass180.06338810
Topological Polar Surface Area118 Ų
Heavy Atom Count12
Formal Charge0
Complexity138
Isotope Atom Count0
Defined Atom Stereocenter Count4
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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41300016-3D-Mannose
GC7397-25gD- (+) -Mannose
RG-A261020-01D (+) -Mannose
abx183971-01D-(+)-Mannose
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