D-Mannose

• Description:

  D-Mannose is a C-2 superpolymer of glucose that occurs naturally in many plants and fruits. D-Mannose has anti-inflammatory and antitumor activity. D-Mannose plays an important role in immune regulation[1][2][3].

• UNSPSC:

  12352211

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Endogenous Metabolite

• Type:

  Natural Products

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Others; Cancer

• Assay Protocol:

  https://www.medchemexpress.com/D-Mannose.html

• Purity:

  98.5

• Solubility:

  DMSO : 50 mg/mL (ultrasonic) |H2O : ≥ 50 mg/mL

• Smiles:

  OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)C=O

• Molecular Formula:

  C6H12O6

• Molecular Weight:

  180.16

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Torretta S, et al. D-mannose suppresses macrophage IL-1β production. Nat Commun. 2020 Dec 11;11 (1) :6343.|[2]Zhang D, et al. D-mannose induces regulatory T cells and suppresses immunopathology. Nat Med. 2017 Sep;23 (9) :1036-1045.|[3]Liu H, et al. D-mannose attenuates bone loss in mice via Treg cell proliferation and gut microbiota-dependent anti-inflammatory effects. Ther Adv Chronic Dis. 2020 Apr 17;11:2040622320912661.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, stored under nitrogen)

• Scientific Category:

  Natural Products

• Clinical Information:

  Phase 4

• Isoform:

  Human Endogenous Metabolite

• CAS Number:

  3458-28-4