Products for Research Use Only
RegisterLogin

Gp91 ds-tat

CAT: 0804-HY-P5381-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-P5381-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Gp91 ds-tat, a biological active peptide, is a NADPH oxidase 2 (Nox2) inhibitor. gp91 ds-tat blocks NADPH oxidase-dependent superoxide production. gp91 ds-tat ameliorates high glucose-induced increase in total ROS, LPOs and iron levels. gp91 ds-tat inhibits homocysteine (Hcy) -induced activation of NLRP3 inflammasomes and restores Hcy-inhibited lysosomal TRPML1 channel activity. gp91 ds-tat improves cerebrovascular and cognitive function in APP/PS1 mice. gp91 ds-tat can be used for the study of Alzheimer’s disease (AD), glomerular inflammation and cardiovascular disease[1][2][3][4].
CAS Number
329902-61-6
UNSPSC
12352209
Target
Ferroptosis; Glutathione Peroxidase; NADPH Oxidase; Reactive Oxygen Species (ROS) ; TRP Channel
Type
Peptides
Related Pathways
Apoptosis; Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Inflammation/Immunology; Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/gp91-ds-tat.html
Purity
98.24
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : ≥ 50 mg/mL
Smiles
O=C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CS)C(N[C@@H](CO)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC(C)C)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCCNC(N)=N)N
Molecular Formula
C98H190N50O22S
Molecular Weight
2452.94
References & Citations
[1]Malaviya P, et al. Role of ferroptosis in mitochondrial damage in diabetic retinopathy. Free Radic Biol Med. 2024 Nov 20;225:821-832. |[2]Ruiz-Uribe NE, et al. Vascular oxidative stress causes neutrophil arrest in brain capillaries, leading to decreased cerebral blood flow and contributing to memory impairment in a mouse model of Alzheimer’s disease. bioRxiv [Preprint]. 2023 Feb 15:2023.02.15.528710.|[3]Li G, et al. Regulation of TRPML1 channel activity and inflammatory exosome release by endogenously produced reactive oxygen species in mouse podocytes. Redox Biol. 2021 Jul;43:102013.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
GPX4

Related Products

CatalogName
HY-P5384Sgp91 ds-tat
HY-P1908Sgp91 ds-tat Peptide 2, scrambled
HY-124131-01DS-437
HY-131182-01DS-1971a
HY-P991365DS-1501
HY-116880DS-2969b
HY-114217DS-003
HY-144401-01DS-3801b
HY-152241-01DS-9300
HY-P991577-01DS-8895

Alternative Products

CatalogName
M37261-01Gp91 ds-tat
CRB1001119-01Gp91 ds-TAT - (TAT Conjugated Peptides)
TP3433-01Sgp91 ds-tat
MBS5789300sgp91 ds-tat Peptide 2, scrambled
317713-01Gp91-phox
C18240DS-1001b (DS 1001)
343544-01Gp91-phox discontinued
MBS8580496-01gp91 phox Antibody

Popular Products