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Dehydroglyasperin D

CAT: 0804-HY-N3716Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-N3716Size:1 Each
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Description
Dehydroglyasperin D inhibits rat and human Aldose Reductase (AR) (IC50: 62.4 μM and 176.2 μM respectively) . Dehydroglyasperin D has anti-obesity, antioxidant effects. Dehydroglyasperin D shows anti-inflammatory activity by inhibiting COX-2 expression and the MLK3 signaling pathway. Dehydroglyasperin D also inhibits melanin synthesis. Dehydroglyasperin D is a prenylated flavonoid that can be isolated from Glycyrrhiza uralensi[1][2][3].
CAS Number
517885-72-2
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Aldose Reductase; COX
Type
Natural Products
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/dehydroglyasperin-d.html
Solubility
10 mM in DMSO
Smiles
OC1=CC=C(C2=CC3=C(OC)C(C/C=C(C)\C)=C(OC)C=C3OC2)C(O)=C1
Molecular Formula
C22H24O5
Molecular Weight
368.42
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Lee YS, et al. Aldose reductase inhibitory compounds from Glycyrrhiza uralensis. Biol Pharm Bull. 2010;33 (5) :917-21.|[2]Jung SK, et al. MLK3 is a novel target of dehydroglyasperin D for the reduction in UVB-induced COX-2 expression in vitro and in vivo. J Cell Mol Med. 2015 Jan;19 (1) :135-42.|[3]Baek EJ, et al. Dehydroglyasperin D Suppresses Melanin Synthesis through MITF Degradation in Melanocytes. J Microbiol Biotechnol. 2022 Aug 28;32 (8) :982-988.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported

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