IM-54

• Description:

  IM-54 is a selective inhibitor of oxidative stress-induced necrosis. IM-54 shows potent inhibitory activity against H2O2-induced necrosis. IM-54 acts as a potential cardioprotective agent and biological tool for investigating the molecular mechanisms of cell death[1][2].

• UNSPSC:

  12352005

• Hazard Statement:

  H301

• Target:

  Necroptosis

• Type:

  Reference compound

• Related Pathways:

  Apoptosis

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/im-54.html

• Purity:

  99.31

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  O=C(C(C1=CN(C)C2=C1C=CC=C2)=C3NCCCCC)N(C)C3=O

• Molecular Formula:

  C19H23N3O2

• Molecular Weight:

  325.40

• Precautions:

  H301

• References & Citations:

  [1]Kosuke Dodo, et al. Indolylmaleimide Derivative IM-17 Shows Cardioprotective Effects in Ischemia-Reperfusion Injury. ACS Med Chem Lett. 2018 Mar 8; 9 (3) : 182-187.|[2]Mikiko Sodeoka, et al. Development of selective inhibitors of necrosis. Chem Rec. 2010 Oct;10 (5) :308-14.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, stored under nitrogen)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [861891-50-1]