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IM-12

CAT: 0804-HY-12292-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-12292-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
IM-12 is an inhibitor of GSK-3β, with an IC50 of 53 nM, and also enhances Wnt signalling.
CAS Number
1129669-05-1
UNSPSC
12352005
Hazard Statement
H301, H311, H331, H341
Target
GSK-3; Wnt
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/IM-12.html
Purity
99.61
Solubility
DMSO : ≥ 54.9 mg/mL
Smiles
O=C(C(NCCC1=CC=C(F)C=C1)=C2C3=C(C)NC4=C3C=CC=C4)N(C)C2=O
Molecular Formula
C22H20FN3O2
Molecular Weight
377.41
Precautions
H301, H311, H331, H341
References & Citations
[1]Schmole AC, et al. Novel indolylmaleimide acts as GSK-3beta inhibitor in human neural progenitor cells. Bioorg Med Chem. 2010 Sep 15;18 (18) :6785-95.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
GSK-3β

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