IM-12

• UNSPSC Description:

  IM-12 is an inhibitor of GSK-3β, with an IC50 of 53 nM, and also enhances Wnt signalling.

• Target Antigen:

  GSK-3

• Type:

  Reference compound

• Related Pathways:

  PI3K/Akt/mTOR;Stem Cell/Wnt

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/IM-12.html

• Purity:

  99.61

• Solubility:

  DMSO : ≥ 54.9 mg/mL

• Smiles:

  O=C(C(NCCC1=CC=C(F)C=C1)=C2C3=C(C)NC4=C3C=CC=C4)N(C)C2=O

• Molecular Weight:

  377.41

• References & Citations:

  [1]Schmole AC, et al. Novel indolylmaleimide acts as GSK-3beta inhibitor in human neural progenitor cells. Bioorg Med Chem. 2010 Sep 15;18(18):6785-95.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  1129669-05-1