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AZD3458

CAT: 0804-HY-112443-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-112443-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AZD3458 is a potent and remarkably selective PI3Kγ inhibitor with pIC50s of 9.1, 5.1, PI3Kγ, PI3Kα, PI3Kβ, and PI3Kδ, respectively[1].
CAS Number
[2132961-46-5]
UNSPSC
12352005
Target
PI3K
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Cancer; Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/PI3K_gamma__inhibitor_3.html
Purity
99.71
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C1N([C@@H](C)C2CC2)CC3=CC(C4=C(C)N=C(NC(C)=O)S4)=CC(S(=O)(C)=O)=C31
Molecular Formula
C20H23N3O4S2
Molecular Weight
433.54
References & Citations
[1]Pemberton N, et al. Discovery of Highly Isoform Selective Orally Bioavailable Phosphoinositide 3-Kinase (PI3K) -γ Inhibitors. J Med Chem. 2018 Jun 28;61 (12) :5435-5441.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PI3KC2α; PI3KC2β; PI3KC2γ; PI3KC3; PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ

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