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AZD3409

CAT: 0804-HY-10062Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-10062Size:1 Each
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AZD3409 is a prenyl inhibitor that exhibits inhibitory activity against both farnesyl transferase and geranylgeranyl transferase I. AZD3409 inhibits the growth of breast cancer cells, with IC50s of 220 nM (MDA-MB-468), 180 nM (MDA-MB-361), and 290 nM (SK-Br-3) . AZD3409 significantly reduces the activation level of AKT in breast cancer cell lines. AZD3409 induces G0/G1 phase arrest in MDA-MB-468 cells, causes G2/M phase arrest in MDA-MB-361 cells. AZD3409 can be used for the study of breast cancer[1].
CAS Number
[345915-10-8]
Product Name Alternative
EBP-921
UNSPSC
12352005
Target
Akt; Farnesyl Transferase
Related Pathways
Metabolic Enzyme/Protease; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
O=C(N[C@@H](CCSC)C(OC(C)C)=O)C1=CC(NC[C@H]2NC[C@H](C2)SC(C3=CN=CC=C3)=O)=CC=C1CCC4=CC=C(F)C=C4
Molecular Formula
C34H41FN4O4S2
Molecular Weight
652.84
References & Citations
[1]Maiello MR, et al. AZD3409 inhibits the growth of breast cancer cells with intrinsic resistance to the EGFR tyrosine kinase inhibitor gefitinib. Breast Cancer Res Treat. 2007 May;102 (3) :275-82.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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