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SIA4A rabbit pAb

CAT: 0855-ES13112-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES13112-01Size:50 µL
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Background
The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein is normally found in the Golgi but can be proteolytically processed to a soluble form. Correct glycosylation of the encoded protein may be critical to its sialyltransferase activity. This protein, which is a member of glycosyltransferase family 29, can use the same acceptor substrates as does sialyltransferase 4B. Two transcript variants encoding the same protein have been found for this gene. Other transcript variants may exist, but have not been fully characterized yet. [provided by RefSeq, Jul 2008]
Description
The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein is normally found in the Golgi but can be proteolytically processed to a soluble form. Correct glycosylation of the encoded protein may be critical to its sialyltransferase activity. This protein, which is a member of glycosyltransferase family 29, can use the same acceptor substrates as does sialyltransferase 4B. Two transcript variants encoding the same protein have been found for this gene. Other transcript variants may exist, but have not been fully characterized yet. [provided by RefSeq, Jul 2008],
UniProt
Q11201
Swiss Prot
Q11201
Reactivity
Human; Mouse
Immunogen
Synthesized peptide derived from human SIA4A AA range: 189-239
Target
SIA4A
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA; IHC
Concentration
1 mg/ml
Dilution
WB 1:500-2000; IHC-p 1:50-300; ELISA 2000-20000
Buffer
-20°C/1 year
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Golgi apparatus, Golgi stack membrane ; Single-pass type II membrane protein . Golgi apparatus, trans-Golgi network membrane ; Single-pass type II membrane protein . Secreted. Membrane-bound form in medial and trans cisternae of Golgi (PubMed:9182658) . Secreted into the body fluid. .
Gene ID (Human)
6482

UniProtKB · Q11201

CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1

SIA4A_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q11201
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ST3GAL1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
Alpha 2,3-ST 1, Beta-galactoside alpha-2,3-sialyltransferase 1
EC number
2.4.3.4
Processing
—
Secondary accessions
O60677, Q9UN51
Protein keywords

PTM

Disulfide bondGlycoprotein

Molecular function

GlycosyltransferaseTransferase

Cellular component

Golgi apparatusMembraneSecreted

Biological process

Lipid metabolism

Technical term

Proteomics identificationReference proteome

Domain

Signal-anchorTransmembraneTransmembrane helix

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