PD-166866

• Description :

  PD166866 is a selective FGFR1 tyrosine kinase inhibitor with an IC50 of 52.4 nM.

• CAS Number :

  [192705-79-6]

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Autophagy; FGFR

• Type :

  Reference compound

• Related Pathways :

  Autophagy; Protein Tyrosine Kinase/RTK

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/PD166866.html

• Purity :

  99.75

• Solubility :

  DMSO : 3.33 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  O=C(NC(C)(C)C)NC1=NC2=NC(N)=NC=C2C=C1C3=CC(OC)=CC(OC)=C3

• Molecular Formula :

  C20H24N6O3

• Molecular Weight :

  396.44

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Panek RL, et al. In vitro biological characterization and antiangiogenic effects of PD 166866, a selective inhibitor of the FGF-1 receptor tyrosine kinase. J Pharmacol Exp Ther. 1998 Jul;286 (1) :569-77.|[2]Thompson AM, Connolly CJ, Hamby JM, et al. 3- (3,5-Dimethoxyphenyl) -1,6-naphthyridine-2,7-diamines and related 2-urea derivatives are potent and selective inhibitors of the FGF receptor-1 tyrosine kinase. J Med Chem. 2000;43 (22) :4200-4211.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 4