PD-166866

• Description:

  PD166866 is a selective FGFR1 tyrosine kinase inhibitor with an IC50 of 52.4 nM.

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Autophagy; FGFR

• Type:

  Reference compound

• Related Pathways:

  Autophagy; Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/PD166866.html

• Purity:

  99.75

• Solubility:

  DMSO : 3.33 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  O=C(NC(C)(C)C)NC1=NC2=NC(N)=NC=C2C=C1C3=CC(OC)=CC(OC)=C3

• Molecular Formula:

  C20H24N6O3

• Molecular Weight:

  396.44

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Panek RL, et al. In vitro biological characterization and antiangiogenic effects of PD 166866, a selective inhibitor of the FGF-1 receptor tyrosine kinase. J Pharmacol Exp Ther. 1998 Jul;286 (1) :569-77.|[2]Thompson AM, Connolly CJ, Hamby JM, et al. 3- (3,5-Dimethoxyphenyl) -1,6-naphthyridine-2,7-diamines and related 2-urea derivatives are potent and selective inhibitors of the FGF receptor-1 tyrosine kinase. J Med Chem. 2000;43 (22) :4200-4211.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 4

• CAS Number:

  [192705-79-6]