HsTX1 (TFA)

CAT: 0804-HY-P5182A-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-P5182A-01Size:1 mg
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Description
HsTX1 (TFA) toxin, from the scorpion Heterometrus spinnifer, is a 34-residue, C-terminally amidated peptide cross-linked by four disulfide bridges. HsTX1 (TFA) is an the inhibitor of potassium channel, with IC50 for Kv1.3 of 12 pM and inhibits TEM cell activation and attenuates inflammation in autoimmunity[1][2][3].
UNSPSC
12352209
Target
Potassium Channel
Type
Peptides
Related Pathways
Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/hstx1-tfa.html
Purity
99.16
Solubility
DMSO : ≥ 100 mg/mL|H2O : 50 mg/mL (ultrasonic)
Smiles
O=C(N[C@@H](CO)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CCSC)C(N[C@@H](CC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@H]1CCCCN)=O)=O)=O)=O)NC2=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H]([C@H](O)C)C(N3[C@@H](CCC3)C(N[C@@H](CCCCN)C(N[C@@H](CC(O)=O)C(N[C@@H](CSSC[C@@H](C(N[C@H]4CCCCN)=O)NC1=O)C(N[C@@H](C)C(N[C@@H](CC(O)=O)C(N5[C@@H](CCC5)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CC(N)=O)C(N[C@H]6CCCNC(N)=N)=O)=O)NC4=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CCC(O)=O)C(N[C@@H]([C@H](O)C)C(NCC(N[C@@H](CSSC[C@@H](C(N)=O)NC6=O)C(N7[C@@H](CCC7)C(N[C@@H](CC8=CC=C(C=C8)O)C(NCC(N[C@H]2CCCCN)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](C)N.O=C(C(F)(F)F)O.[x]
Molecular Formula
C149H246N54O46S9.xC2HF3O2
Molecular Weight
3818.47 (free base)
References & Citations
[3]Lebrun, Bruno, et al. A four-disulphide-bridged toxin, with high affinity towards voltage-gated K+ channels, isolated from Heterometrus spinnifer (Scorpionidae) venom. Biochemical Journal. 328 (Pt 1) : 321–327.|[1]M Harunur Rashid, et al. A potent and Kv1.3-selective analogue of the scorpion toxin HsTX1 as a potential therapeutic for autoimmune diseases. Sci Rep. 2014 Mar 28:4:4509. doi: 10.1038/srep04509.|[2]Mark R. Tanner, et al. Prolonged immunomodulation in inflammatory arthritis using the selective Kv1.3 channel blocker HsTX1[R14A] and its PEGylated analog. Immunol. 2017 Jul; 180: 45–57. Published online 2017 Apr 4.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported

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