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CPI-1189

CAT: 0804-HY-100376-05Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-100376-05Size:50 mg
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Description
CPI-1189 is an orally active TNF-α release inhibitor. CPI-1189 inhibits phosphorylation of p38. CPI-1189 can inhibit apoptosis. CPI-1189 can be used in the study of HIV and neurological diseases[1][2][3][4][5].
CAS Number
183619-38-7
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; TNF Receptor
Type
Reference compound
Related Pathways
Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Infection; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/cpi-1189.html
Purity
99.82
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NC(C)(C)C)C1=CC=C(NC(C)=O)C=C1
Molecular Formula
C13H18N2O2
Molecular Weight
234.30
Precautions
H302, H315, H319, H335
References & Citations
[1]Müller T. CPI-1189. Centaur. Curr Opin Investig Drugs. 2002 Dec;3 (12) :1763-7. |[2]Clifford DB, et al. A randomized clinical trial of CPI-1189 for HIV-associated cognitive-motor impairment. Neurology. 2002 Nov 26;59 (10) :1568-73.|[3]Li YJ, et al. CPI-1189 protects neuronal cells from oxygen glucose deprivation/re-oxygenation-induced oxidative injury and cell death. Aging (Albany NY) . 2021 Feb 17;13 (5) :6712-6723.|[4]Hensley K, et al. CPI-1189 inhibits interleukin 1beta-induced p38-mitogen-activated protein kinase phosphorylation: an explanation for its neuroprotective properties? Neurosci Lett. 2000 Mar 10;281 (2-3) :179-82.|[5]Bjugstad KB, et al. Preventive actions of a synthetic antioxidant in a novel animal model of AIDS dementia. Brain Res. 1998 Jun 8;795 (1-2) :349-57.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2

Chemical Information

Cpi 1189

CPI-1189 has been used in trials studying the treatment of HIV Infections and AIDS Dementia Complex.

CAS Number183619-38-7
PubChem CID151118
IUPAC Name4-acetamido-N-tert-butylbenzamide
Molecular FormulaC13H18N2O2
Molecular Weight234.29
XLogP2
Topological Polar Surface Area58.2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count2
Rotatable Bond Count3
Heavy Atom Count17
Formal Charge0
Complexity286
SMILES
CC(=O)NC1=CC=C(C=C1)C(=O)NC(C)(C)C
InChI
InChI=1S/C13H18N2O2/c1-9(16)14-11-7-5-10(6-8-11)12(17)15-13(2,3)4/h5-8H,1-4H3,(H,14,16)(H,15,17)
InChIKey
DJKNRCWSXSZACF-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Cpi 1189
CAS: 183619-38-7
CID: 151118
Formula: C13H18N2O2
MW: 234.29
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight234.29
XLogP32
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count2
Rotatable Bond Count3
Exact Mass234.136827821
Monoisotopic Mass234.136827821
Topological Polar Surface Area58.2 Ų
Heavy Atom Count17
Formal Charge0
Complexity286
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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