CPI-1328

• Description:

  CPI-1328 is an EZH2 inhibitor with a Ki value of 63 fM.

• UNSPSC:

  12352005

• Target:

  Histone Methyltransferase

• Type:

  Reference compound

• Related Pathways:

  Epigenetics

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/cpi-1328.html

• Solubility:

  10 mM in DMSO

• Smiles:

  ClC1=C2C(O[C@](O2)([C@]3([H])CC[C@H](CC3)N(C)C)C)=C(C4=C1CCN(C4=O)CC5=C(C=C(NC5=O)C)SC)C

• Molecular Formula:

  C28H36ClN3O4S

• Molecular Weight:

  546.12

• References & Citations:

  [1]Stuckey JI, et al. Identification and characterization of second-generation EZH2 inhibitors with extended residence times and improved biological activity. J Biol Chem. 2021 Jan-Jun;296:100349.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  EZH2

• CAS Number:

  [2390367-27-6]