B7/CD28 interaction inhibitor 1

B7/CD28 interaction inhibitor 1

• CAS Number: 635324-72-0
• UNSPSC Description: B7/CD28 interaction inhibitor 1 (copmound 6b) is a potent B7.1-CD28 interaction inhibitor with an IC50 of 50 nM[1].
• Target Antigen: CD28
• Type: Reference compound
• Related Pathways: Immunology/Inflammation
• Applications: COVID-19-anti-virus
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/ctla-4-inhibitor-1.html
• Purity: 99.47
• Solubility: DMSO : 62.5 mg/mL (ultrasonic)
• Smiles: O=C1N(C2=CC=C(F)C=C2)NC3=C4C(N(C)N=C4)=NC(C5=CC=CC(C(F)(F)F)=C5)=C31
• Molecular Weight: 427.35
• References & Citations: [1]Green NJ, et al. Structure-activity studies of a series of dipyrazolo[3,4-b:3',4'-d]pyridin-3-ones binding to the immune regulatory protein B7.1. Bioorg Med Chem. 2003 Jul 3;11(13):2991-3013.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported