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AS601245 (TFA)

CAT: 0804-HY-11010ASize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-11010ASize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AS601245 TFA is an orally active, selective, ATP competitive JNK (c-Jun NH2-terminal protein kinase) inhibitor with IC50s of 150, 220, and 70 nM for three JNK human isoforms (hJNK1, hJNK2, and hJNK3), respectively. AS601245 TFA exhibits 10- to 20-fold selectivity over c-src, CDK2, and c-Raf and more than 50- to 100-fold selectivity over a range of Ser/Thr- and Tyr-protein kinases. Neuroprotective properties[1][2].
CAS Number
345987-16-8
UNSPSC
12352005
Target
JNK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Field of Research
Cancer; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/as601245-tfa.html
Solubility
10 mM in DMSO
Smiles
N#CC(C1=CC=NC(NCCC2=CC=CN=C2)=N1)C3=NC4=CC=CC=C4S3.OC(C(F)(F)F)=O.OC(C(F)(F)F)=O
Molecular Formula
C24H18F6N6O4S
Molecular Weight
600.49
References & Citations
[1]Carboni S, et al. AS601245 (1,3-benzothiazol-2-yl (2-[[2- (3-pyridinyl) ethyl] amino]-4 pyrimidinyl) acetonitrile) : a c-Jun NH2-terminal protein kinase inhibitor with neuroprotective properties. J Pharmacol Exp Ther. 2004;310 (1) :25-32.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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