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NLRP3-IN-54

CAT: 0804-HY-168503Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-168503Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NLRP3-IN-54 (Compound C4) is an NLRP3 inhibitor. NLRP3-IN-54 can significantly reduce the levels of active Caspase-1 and active IL-1β (IC50 = 0.805 μM), can be used for inflammation research[1].
UNSPSC
12352101
Target
Interleukin Related; NOD-like Receptor (NLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/nlrp3-in-54.html
Smiles
O=C(NS(=O)(C1=CC(Br)=CC2=C1OCC2)=O)NC3=C(C=C(C=C3Br)Cl)OC4=CC=CC=C4
Molecular Formula
C21H15Br2ClN2O5S
Molecular Weight
602.68
References & Citations
[1]Feng H, et al. Design, synthesis and biological evaluation of sulfonylurea derivatives as NLRP3 inflammasome inhibitors[J]. Bioorganic & Medicinal Chemistry Letters, 2024: 129987.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IL-1

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