NLRP3-IN-54

NLRP3-IN-54

• UNSPSC Description: NLRP3-IN-54 (Compound C4) is an NLRP3 inhibitor. NLRP3-IN-54 can significantly reduce the levels of active Caspase-1 and active IL-1β (IC50 = 0.805 μM), can be used for inflammation research[1].
• Target Antigen: Interleukin Related; NOD-like Receptor (NLR)
• Type: Reference compound
• Related Pathways: Immunology/Inflammation
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/nlrp3-in-54.html
• Smiles: O=C(NS(=O)(C1=CC(Br)=CC2=C1OCC2)=O)NC3=C(C=C(C=C3Br)Cl)OC4=CC=CC=C4
• Molecular Weight: 602.68
• References & Citations: [1]Feng H, et al. Design, synthesis and biological evaluation of sulfonylurea derivatives as NLRP3 inflammasome inhibitors[J]. Bioorganic & Medicinal Chemistry Letters, 2024: 129987.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported