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Veratridine (Standard)

CAT: 0804-HY-N6691RSize: 1 EachDry Ice: NoHazardous: No
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Description
Veratridine (Standard) is the analytical standard of Veratridine. This product is intended for research and analytical applications. Veratridine (3-Veratroylveracevine) is a plant neurotoxin, a voltage-gated sodium channels (VGSCs) agonist. Veratridine inhibits the peak current of Nav1.7, with an IC50 of 18.39?μM. Veratridine regulates sodium ion channels mainly by activating sodium ion channels, preventing channel inactivation and increasing sodium ion flow[1][2].
CAS Number
71-62-5
Product Name Alternative
3-Veratroylveracevine (Standard)
UNSPSC
12352005
Target
Reference Standards; Sodium Channel
Type
Reference Standards
Related Pathways
Membrane Transporter/Ion Channel; Others
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/veratridine-standard.html
Smiles
C[C@@]12[C@]34[C@](CC[C@]1([H])[C@@](O)([C@@H](OC(C5=CC(OC)=C(OC)C=C5)=O)CC2)O4)([H])[C@@]6(O)[C@](O)([C@@]7([H])[C@@](O)([C@](O)([C@@]8([H])N(C[C@@H](C)CC8)C7)C)[C@@H](O)C6)C3
Molecular Formula
C36H51NO11
Molecular Weight
673.79
References & Citations
[1]Zhang XY, et al. Veratridine modifies the gating of human voltage-gated sodium channel Nav1.7. Acta Pharmacol Sin. 2018 Nov;39 (11) :1716-1724.|[2]Laura A Uribe, et al. Supramolecular Complexes of Plant Neurotoxin Veratridine with Cyclodextrins and Their Antidote-like Effect on Neuro-2a Cell Viability. Pharmaceutics. 2022 Mar 9;14 (3) :598.|[3]Zainab A Mohammed, et al. Veratridine produces distinct calcium response profiles in mouse Dorsal Root Ganglia neurons. Sci Rep. 2017 Mar 24;7:45221.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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