SAH

• Description:

  SAH (S-Adenosylhomocysteine) is an amino acid derivative and a modulartor in several metabolic pathways. It is an intermediate in the synthesis of cysteine and adenosine[1]. SAH is an inhibitor for METTL3-METTL14 heterodimer complex (METTL3-14) with an IC50 of 0.9 µM[2].

• Product Name Alternative:

  SAH (S-Adenosylhomocysteine)

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Endogenous Metabolite

• Type:

  Natural Products

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/SAH.html

• Purity:

  99.90

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  NC1=NC=NC2=C1N=CN2[C@@H]3O[C@H](CSCC[C@H](N)C(O)=O)[C@@H](O)[C@H]3O

• Molecular Formula:

  C14H20N6O5S

• Molecular Weight:

  384.41

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]DE LA HABA G, et al. The enzymatic synthesis of S-adenosyl-L-homocysteine from adenosine and homocysteine. J Biol Chem. 1959 Mar;234 (3) :603-8.|[2]Li F, et al. A Radioactivity-Based Assay for Screening Human m6A-RNA Methyltransferase, METTL3-METTL14 Complex, and Demethylase ALKBH5. Biomol Screen. 2016 Mar;21 (3) :290-7.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, protect from light)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• Isoform:

  Human Endogenous Metabolite

• CAS Number:

  979-92-0