Products for Research Use Only
RegisterLogin

Amifostine thiol

CAT: 0804-HY-137864-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-137864-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Amifostine thiol (WR-1065) is an active metabolite of the cytoprotector Amifostine. Amifostine thiol is a cytoprotective agent with radioprotective abilities. Amifostine thiol activates p53 through a JNK-dependent signaling pathway[1][2][3].
CAS Number
31098-42-7
Product Name Alternative
WR-1065
UNSPSC
12352211
Hazard Statement
H302, H312, H332
Target
MDM-2/p53
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/amifostine-thiol.html
Purity
95.0
Solubility
H2O : 250 mg/mL (ultrasonic)
Smiles
NCCCNCCS
Molecular Formula
C5H14N2S
Molecular Weight
134.24
Precautions
H302, H312, H332
References & Citations
[1]Jaroslaw Dziegielewski, et al. WR-1065, the Active Metabolite of Amifostine, Mitigates Radiation-Induced Delayed Genomic Instability. Free Radic Biol Med. 2008 Dec 15; 45 (12) : 1674-1681.|[2]Olivier Pluquet, et al. The cytoprotective aminothiol WR1065 activates p53 through a non-genotoxic signaling pathway involving c-Jun N-terminal kinase. J Biol Chem. 2003 Apr 4;278 (14) :11879-87. J Biol Chem. 2003 Apr 4;278 (14) :11879-87.|[3]J. S. Murley, et al. WR-1065, an active metabolite of the cytoprotector amifostine, affects phosphorylation of topoisomerase IIα leading to changes in enzyme activity and cell cycle progression in CHO AA8 cells. Cell Prolif. 1997 Jun; 30 (6) : 283-294.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-B0639-01Amifostine
HY-B0639A-01Amifostine (trihydrate)
HY-B0639CAmifostine (sodium)
HY-130601-01Thiol-PEG5-thiol
HY-W022204Thiol-PEG2-thiol
HY-135963-01Thiol-PEG3-thiol
HY-W678394-01DOTA-Thiol
HY-108715Real Thiol
HY-W441004-01DSPE-Thiol
HY-111823-01VH032 thiol

Alternative Products

CatalogName
MBS5798409Amifostine thiol
001911Amifostine Thiol Dihydrochloride
AR-A06157-01Amifostine Thiol Ditrifluoroacetate
441351-01Amifostine Thiol-13C3 Dihydrochloride
TRC-A576822-50MGAmifostine Thiol Dihydrochloride-d4
TRC-A576820-50MGAmifostine Thiol Dihydrochloride >90%
AR-A06158-01Amifostine Thiol-d6 Ditrifluoroacetate

Popular Products