Amifostine

CAT: 0804-HY-B0639-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-B0639-01Size:5 mg
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Description
Amifostine (WR2721) is a broad-spectrum cytoprotective agent and a radioprotector. Amifostine selectively protects normal tissues from damage caused by radiation and chemotherapy. Amifostine is potent hypoxia-inducible factor-α1 (HIF-α1) and p53 inducer. Amifostine protects cells from damage by scavenging oxygen-derived free radicals. Amifostine reduces renal toxicity and has antiangiogenic action[1][2][3][4].
CAS Number
[20537-88-6]
Product Name Alternative
WR2721
UNSPSC
12352211
Hazard Statement
H302
Target
HIF/HIF Prolyl-Hydroxylase; MDM-2/p53
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Amifostine.html
Purity
99.95
Solubility
DMSO : < 1 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)
Smiles
OP(SCCNCCCN)(O)=O
Molecular Formula
C5H15N2O3PS
Molecular Weight
214.22
Precautions
H302
References & Citations
[1]Kouvaris, J.R., V.E. Kouloulias, and L.J. Vlahos, Amifostine: the first selective-target and broad-spectrum radioprotector. Oncologist, 2007. 12 (6) : p. 738-47.|[2]D Maurici, et al. Amifostine (WR2721) restores transcriptional activity of specific p53 mutant proteins in a yeast functional assay. Oncogene. 2001 Jun 14;20 (27) :3533-40.|[3]Efstathia Giannopoulou, et al. Amifostine inhibits angiogenesis in vivo. J Pharmacol Exp Ther. 2003 Feb;304 (2) :729-37.|[4]Michael I Koukourakis, et al. Amifostine induces anaerobic metabolism and hypoxia-inducible factor 1 alpha. Cancer Chemother Pharmacol. 2004 Jan;53 (1) :8-14.|[5]Shao-Ze Wu, et al. Amifostine Pretreatment Attenuates Myocardial Ischemia/Reperfusion Injury by Inhibiting Apoptosis and Oxidative Stress. Oxid Med Cell Longev. 2017;2017:4130824.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched

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