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TK216

CAT: 0804-HY-122903-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-122903-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TK216 is an orally active and potent E26 transformation specific (ETS) inhibitor[1]. TK216 directly binds EWS-FLI1 and inhibits EWS-FLI1 protein interactions. TK216 blocks the binding between EWS-FLI1 and RNA helicase A. TK216 has anticancer activity[2].
CAS Number
1903783-48-1
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tk216.html
Concentration
10mM
Purity
99.84
Solubility
DMSO : ≥ 250 mg/mL
Smiles
O=C1NC2=C(C(Cl)=CC=C2Cl)C1(CC(C3=CC=C(C4CC4)C=C3)=O)O
Molecular Formula
C19H15Cl2NO3
Molecular Weight
376.23
Precautions
H302, H315, H319, H335
References & Citations
[1]Brian Lannutti, et al. Uses of indolinone compounds. US10159660B2.|[2]Spriano F, et al. The ETS Inhibitors YK-4-279 and TK-216 Are Novel Antilymphoma Agents. Clin Cancer Res. 2019 Aug 15;25 (16) :5167-5176.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2

Chemical Information

4,7-Dichloro-3-(2-(4-cyclopropylphenyl)-2-oxoethyl)-3-hydroxyindolin-2-one
CAS Number1903783-48-1
PubChem CID121268274
IUPAC Name4,7-dichloro-3-[2-(4-cyclopropylphenyl)-2-oxoethyl]-3-hydroxy-1H-indol-2-one
Molecular FormulaC19H15Cl2NO3
Molecular Weight376.2
XLogP4.1
Topological Polar Surface Area66.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Heavy Atom Count25
Formal Charge0
Complexity559
SMILES
C1CC1C2=CC=C(C=C2)C(=O)CC3(C4=C(C=CC(=C4NC3=O)Cl)Cl)O
InChI
InChI=1S/C19H15Cl2NO3/c20-13-7-8-14(21)17-16(13)19(25,18(24)22-17)9-15(23)12-5-3-11(4-6-12)10-1-2-10/h3-8,10,25H,1-2,9H2,(H,22,24)
InChIKey
ZWHNLSHDLKIXOG-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 4,7-Dichloro-3-(2-(4-cyclopropylphenyl)-2-oxoethyl)-3-hydroxyindolin-2-one
CAS: 1903783-48-1
CID: 121268274
Formula: C19H15Cl2NO3
MW: 376.2
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight376.2
XLogP34.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Exact Mass375.0428987
Monoisotopic Mass375.0428987
Topological Polar Surface Area66.4 Ų
Heavy Atom Count25
Formal Charge0
Complexity559
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
BA3968-5.1TK216
T39329-01(+)-TK216
OR1073948-01(-) -TK216
T39330-01(-)-TK216

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