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TK216

CAT: 0013-GTR19175700-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19175700-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TK216 is a potent and selective small molecule inhibitor of the E26 transformation-specific (ETS) family of transcription factors. It demonstrates anticancer activity in preclinical studies, showing efficacy in both in vitro cellular assays and in vivo xenograft models of ETS-dependent cancers.
CAS Number
1903783-48-1
Product Name Alternative
Leukemia, Friend, Ewing, EWS-FLI1, EST, ETS, Inhibitor, inhibit, E26, DNASynthesis, DNA/RNA Synthesis, DNA Synthesis, anticancer, transcription, virus, TK216, TK-216, TK 216, proliferation, RNASynthesis, RNA, RNA Synthesis, sarcoma
Field of Research
Cell Biology, Molecular Biology
Purity
97.22% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (13.29 mM) ; DMSO:249 mg/mL (661.83 mM)
Smiles
OC1 (CC (=O) c2ccc (cc2) C2CC2) C (=O) Nc2c1c (Cl) ccc2Cl
Molecular Formula
C19H15Cl2NO3
Molecular Weight
376.23
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

4,7-Dichloro-3-(2-(4-cyclopropylphenyl)-2-oxoethyl)-3-hydroxyindolin-2-one
CAS Number1903783-48-1
PubChem CID121268274
IUPAC Name4,7-dichloro-3-[2-(4-cyclopropylphenyl)-2-oxoethyl]-3-hydroxy-1H-indol-2-one
Molecular FormulaC19H15Cl2NO3
Molecular Weight376.2
XLogP4.1
Topological Polar Surface Area66.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Heavy Atom Count25
Formal Charge0
Complexity559
SMILES
C1CC1C2=CC=C(C=C2)C(=O)CC3(C4=C(C=CC(=C4NC3=O)Cl)Cl)O
InChI
InChI=1S/C19H15Cl2NO3/c20-13-7-8-14(21)17-16(13)19(25,18(24)22-17)9-15(23)12-5-3-11(4-6-12)10-1-2-10/h3-8,10,25H,1-2,9H2,(H,22,24)
InChIKey
ZWHNLSHDLKIXOG-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 4,7-Dichloro-3-(2-(4-cyclopropylphenyl)-2-oxoethyl)-3-hydroxyindolin-2-one
CAS: 1903783-48-1
CID: 121268274
Formula: C19H15Cl2NO3
MW: 376.2
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight376.2
XLogP34.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Exact Mass375.0428987
Monoisotopic Mass375.0428987
Topological Polar Surface Area66.4 Ų
Heavy Atom Count25
Formal Charge0
Complexity559
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
BA3968-5.1TK216
T39329-01(+)-TK216
HY-122903A-01(-) -TK216
HY-122903B-01(+) -TK216
T39330-01(-)-TK216
HY-122903S-01TK216-d4

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