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TK216

CAT: 0804-HY-122903-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-122903-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TK216 is an orally active and potent E26 transformation specific (ETS) inhibitor[1]. TK216 directly binds EWS-FLI1 and inhibits EWS-FLI1 protein interactions. TK216 blocks the binding between EWS-FLI1 and RNA helicase A. TK216 has anticancer activity[2].
CAS Number
1903783-48-1
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tk216.html
Concentration
10mM
Purity
99.84
Solubility
DMSO : ≥ 250 mg/mL
Smiles
O=C1NC2=C(C(Cl)=CC=C2Cl)C1(CC(C3=CC=C(C4CC4)C=C3)=O)O
Molecular Formula
C19H15Cl2NO3
Molecular Weight
376.23
Precautions
H302, H315, H319, H335
References & Citations
[1]Brian Lannutti, et al. Uses of indolinone compounds. US10159660B2.|[2]Spriano F, et al. The ETS Inhibitors YK-4-279 and TK-216 Are Novel Antilymphoma Agents. Clin Cancer Res. 2019 Aug 15;25 (16) :5167-5176.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2

Alternative Products

CatalogName
BA3968-5.1TK216
T39329-01(+)-TK216
OR1073948-01(-) -TK216
T39330-01(-)-TK216

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