Chlorotoxin (TFA)

• UNSPSC Description:

  Chlorotoxin TFA is a peptide isolated from the venom of the scorpion Leiurus quinquestriatus, acts as a chloride channel blocker[1]. Anti-cancer activity[2].

• Target Antigen:

  Chloride Channel

• Type:

  Peptides

• Related Pathways:

  Membrane Transporter/Ion Channel

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/chlorotoxin-tfa.html

• Purity:

  98.53

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)|H2O : 33.33 mg/mL (ultrasonic)

• Smiles:

  O=C(N[C@@H](CSSC[C@@H](C(N[C@@H](CSSC[C@@H](C(N[C@@H](CCCNC(N)=N)C(N)=O)=O)NC1=O)C(NCC(NCC(N[C@@H](CCCCN)C(NCC(N[C@@H](CCCNC(N)=N)C(NCC(N[C@H]2CCCCN)=O)=O)=O)=O)=O)=O)=O)=O)NC3=O)C(N[C@@H](CCSC)C(N4[C@@H](CCC4)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CC5=CC=C(C=C5)O)C(NCC(N6[C@@H](CCC6)C(N[C@H]7CCC(N)=O)=O)=O)=O)=O)NC2=O)C(N[C@@H](CC8=CC=CC=C8)C(N[C@@H]([C@H](O)C)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(O)=O)C(N[C@@H](CC9=CNC=N9)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCSC)C(N[C@@H](C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CSSC[C@@H](C(N[C@H]1CC(C)C)=O)NC7=O)C(N[C@@H](CC(O)=O)C(N[C@H]3CC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCSC)N.OC(C(F)(F)F)=O

• Molecular Weight:

  3995.71 (free base)

• References & Citations:

  [1]DeBin JA, et al. Purification and characterization of chlorotoxin, a chloride channel ligand from the venom of the scorpion. Am J Physiol. 1993 Feb;264(2 Pt 1):C361-9.|[2]Ojeda PG, et al. Chlorotoxin: Structure, activity, and potential uses in cancer therapy. Biopolymers. 2016 Jan;106(1):25-36.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)

• Clinical Information:

  Phase 1