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Chlorotoxin

CAT: 0804-HY-P0173A-01Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0804-HY-P0173A-01Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Chlorotoxin is a 36 amino-acid peptide from the venom of the Israeli scorpion Leiurus quinquestriatus with anticancer activity. Chlorotoxin is a chloride channel blocker.
CAS Number
163515-35-3
UNSPSC
12352209
Target
Chloride Channel
Type
Peptides
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Chlorotoxin.html
Purity
98.54
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 5 mg/mL (ultrasonic)
Smiles
O=C(N[C@@H](CSSC[C@@H]1NC2=O)C(N[C@@H](CCSC)C(N3[C@@H](CCC3)C(N[C@@H](CSSC[C@@H](C(NCC(NCC(N[C@@H](CCCCN)C(NCC(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H](CCCCN)C(N[C@@H](CS4)C(N[C@@H](CC5=CC=C(C=C5)O)C(NCC(N6[C@@H](CCC6)C(N[C@@H](CCC(N)=O)C(N[C@@H](CS)C(N[C@H]7CC(C)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)NC1=O)C(N[C@@H](CC8=CC=CC=C8)C(N[C@@H]([C@H](O)C)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(O)=O)C(N[C@@H](CC9=CNC=N9)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCS4C)C(N[C@@H](C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CCCNC(N)=N)C(N)=O)=O)NC7=O)C(N[C@@H](CC(O)=O)C(N[C@H]2CC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCSC)N
Molecular Formula
C158H249N53O47S11
Molecular Weight
3995.71
References & Citations
[1]DeBin JA, et al. Purification and characterization of chlorotoxin, a chloride channel ligand from the venom of the scorpion. Am J Physiol. 1993 Feb;264 (2 Pt 1) :C361-9.|[2]Ojeda PG, et al. Chlorotoxin: Structure, activity, and potential uses in cancer therapy. Biopolymers. 2016 Jan;106 (1) :25-36.|[3]Soroceanu L, et al. Use of chlorotoxin for targeting of primary brain tumors. Cancer Res. 1998 Nov 1;58 (21) :4871-9.|[4]Dardevet L, et al. Chlorotoxin: a helpful natural scorpion peptide to diagnose glioma and fight tumor invasion. Toxins (Basel) . 2015 Mar 27;7 (4) :1079-101.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
Phase 2
Citation 01
Pain. 2021 Jun 1;162 (6) :1882-1896.|Biochim Biophys Acta Mol Basis Dis. 2025 Sep 2;1872 (1) :168030.

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