DL-threo-PDMP (hydrochloride)
CAT:
804-HY-116392B-02
Size:
5 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
DL-threo-PDMP (hydrochloride)
- Product Name Alternative: 4'-Fluoro-5'-O-sulfamoyladenosine; NSC 521007
- CAS Number: 80938-69-8
- UNSPSC Description: DL-threo-PDMP hydrochloride is the hydrochloride form of DL-threo-PDMP that is a competitive glucosylceramide synthase (GCS) inhibitor. DL-threo-PDMP resensitizes refractory testicular germ cell tumors and epithelial ovarian cancer orthoxenografts to cisplatin in mice[1].
- Target Antigen: Glucosylceramide Synthase (GCS)
- Type: Reference compound
- Related Pathways: Neuronal Signaling
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/dl-threo-pdmp-hydrochloride.html
- Purity: 98.4
- Solubility: DMSO : 30 mg/mL (ultrasonic;warming)
- Smiles: O[C@H](C1=CC=CC=C1)[C@H](NC(CCCCCCCCC)=O)CN2CCOCC2.Cl
- Molecular Weight: 427.02
- References & Citations: [1]Piulats JM, et al. Orthoxenografts of Testicular Germ Cell Tumors Demonstrate Genomic Changes Associated with Cisplatin Resistance and Identify PDMP as a Resensitizing Agent. Clin Cancer Res. 2018 Aug 1;24(15):3755-3766.
- Shipping Conditions: Blue Ice
- Storage Conditions: -20°C (Powder, stored under nitrogen, away from moisture)
- Clinical Information: No Development Reported