PDMP (hydrochloride)

CAT: 0931-MF-0044730-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0044730-01Size:10 mg
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CAS Number
73257-80-4
Target
Others|||Apoptosis|||Transferase
Related Pathways
Metabolism|||Others|||Apoptosis
Bioactivity
PDMP is a ceramide analog first prepared in a search for inhibitors of glucosylceramide synthase. PDMP has two adjacent chiral centers (C1 and C2) allowing for the formation of four possible isomers. PDMP contains all four of these stereoisomers. PDMP inhibits glucosylceramide synthase by 90% when used at a concentration of 0.8 ?M in MDCK cell homogenates, however, the ability to inhibit glucosylceramide synthase has been found to reside in the D-threo (1R,2R) enantiomer. The D-threo PDMP enantiomer is also responsible for inhibition of ?-1,4-galactosyltransferase 6 and prevention of lactosylceramide synthesis, which is a promotor of neuroinflammation in mice during chronic experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis. PDMP enhances curcumin-induced inhibition of proliferation, JNK activation, and Akt inhibition, as well as induction of apoptosis in WM-115 melanoma cells in vitro.
Smiles
Cl.CCCCCCCCCC(=O)NC(CN1CCOCC1)C(O)c1ccccc1
Molecular Formula
C23H39ClN2O3
Molecular Weight
427.03
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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