AD57 (hydrochloride)

• UNSPSC Description:

  AD57 hydrochloride is an orally active multikinase inhibitor, inhibits RET, BRAF, S6K and Src[1].

• Target Antigen:

  Raf; RET; Ribosomal S6 Kinase (RSK); Src

• Type:

  Reference compound

• Related Pathways:

  MAPK/ERK Pathway;Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/ad57-hydrochloride.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(NC1=CC=CC(C(F)(F)F)=C1)NC2=CC=C(C3=NN(C(C)C)C4=C3C(N)=NC=N4)C=C2.[H]Cl

• Molecular Weight:

  491.90

• References & Citations:

  [1]Dar AC, et al. Chemical genetic discovery of targets and anti-targets for cancer polypharmacology. Nature. 2012 Jun 6;486(7401):80-4.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2320261-72-9