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Alpha-Bisabolol

CAT: 0804-HY-121222-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0804-HY-121222-01Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Alpha-Bisabolol, an orally active sesquiterpene alcohol, induces cell cycle arrest, mitochondrial apoptosis and inhibition of PI3K/Akt signalling pathways. alpha-Bisabolol exerts a protective action against Cisplatin -induced nephrotoxicity by mitigating inflammation and oxidative stress through the inhibition of NFκB activation. alpha-Bisabolol exhibits anti-inflammatory, analgesic, antibiotic and anticancer activities[1][2].
CAS Number
515-69-5
UNSPSC
12352211
Hazard Statement
H302, H311, H319, H413
Target
Apoptosis; PI3K
Type
Natural Products
Related Pathways
Apoptosis; PI3K/Akt/mTOR
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/alpha-bisabolol.html
Purity
80.0
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C/C(C)=C\CC[C@@](O)([C@@H]1CCC(C)=CC1)C
Molecular Formula
C15H26O
Molecular Weight
222.37
Precautions
H302, H311, H319, H413
References & Citations
[1]Wu S, et al. Anticancer effects of α-Bisabolol in human non-small cell lung carcinoma cells are mediated via apoptosis induction, cell cycle arrest, inhibition of cell migration and invasion and upregulation of P13K/AKT signalling pathway. J BUON. 2018 Sep-Oct;23 (5) :1407-1412.|[2]Nur Elena Zaaba, et al. The Nephroprotective Effects of α-Bisabolol in Cisplatin-Induced Acute Kidney Injury in Mice. Biomedicines. 2022 Apr 3;10 (4) :842.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
PI3K

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