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Cefotaxime (sodium)

CAT: 0804-HY-A0088-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-A0088-01Size:500 mg
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Description
Cefotaxime (Cefotaxim) sodium, a β-lactamase stable cephalosporin and a third-generation cephalosporin antibiotic, possesses broad-spectrum antibiotic activity against numerous Gram-positive and Gram-negative bacteria[1][2][3][4][5].
CAS Number
64485-93-4
Product Name Alternative
Cefotaxim (sodium) ; HR-756 (sodium)
UNSPSC
12352005
Hazard Statement
H317, H334
Target
Antibiotic; Bacterial; Beta-lactamase
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/cefotaxime-sodium.html
Concentration
10mM
Purity
99.12
Solubility
DMSO : 45 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic)
Smiles
O=C(C(N12)=C(COC(C)=O)CS[C@]2([H])[C@H](NC(/C(C3=CSC(N)=N3)=N\OC)=O)C1=O)O[Na]
Molecular Formula
C16H16N5NaO7S2
Molecular Weight
477.45
Precautions
H317, H334
References & Citations
[1]Woodfield JC, et al. A comparison of the prophylactic efficacy of ceftriaxone and cefotaxime in abdominal surgery. Am J Surg. 2003 Jan;185 (1) :45-9.|[2]Scholz H, et al. Prospective comparison of ceftriaxone and cefotaxime for the short-term treatment of bacterial meningitis in children. Chemotherapy. 1998 Mar-Apr;44 (2) :142-7.|[3]E L Francke, et al. Use of cefotaxime, a beta-lactamase stable cephalosporin, in the therapy of serious infections, including those due to multiresistant organisms. Am J Med. 1981 Sep;71 (3) :435-42.|[4]Gums JG, et al. Differences between ceftriaxone and cefotaxime: microbiological inconsistencies. Ann Pharmacother. 2008 Jan;42 (1) :71-9.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
β-lactam
Citation 01
Biomed Chromatogr. 2024 Jul 8:e5955.|Chin J Traumatol. 2024 Jul 3:S1008-1275 (24) 00075-0.|ACS Environ Au. 2025 Aug 8.|AMB Express. 2024 Dec 24;14 (1) :141.|Anal Chem. 2025 Jun 3;97 (21) :11099-11109.|bioRxiv. 2024 May 10.|Cell. 2025 Mar 6;188 (5) :1330-1348.e27.|Int J Antimicrob Agents. 2025 Jun 9:107551.|J Antibiot (Tokyo) . 2025 Mar;78 (4) :265-273.|Molecules. 2025 Mar 9;30 (6) :1224.

Chemical Information

Cefotaxime Sodium

Cefotaxime sodium is a cephalosporin organic sodium salt having acetoxymethyl and [2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino side-groups. It contains a cefotaxime(1-).

CAS Number64485-93-4
PubChem CID10695961
IUPAC Namesodium (6R,7R)-3-(acetyloxymethyl)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
Molecular FormulaC16H16N5NaO7S2
Molecular Weight477.5
Topological Polar Surface Area230
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count12
Rotatable Bond Count8
Heavy Atom Count31
Formal Charge0
Complexity839
SMILES
CC(=O)OCC1=C(N2[C@@H]([C@@H](C2=O)NC(=O)/C(=N\OC)/C3=CSC(=N3)N)SC1)C(=O)[O-].[Na+]
InChI
InChI=1S/C16H17N5O7S2.Na/c1-6(22)28-3-7-4-29-14-10(13(24)21(14)11(7)15(25)26)19-12(23)9(20-27-2)8-5-30-16(17)18-8;/h5,10,14H,3-4H2,1-2H3,(H2,17,18)(H,19,23)(H,25,26);/q;+1/p-1/b20-9-;/t10-,14-;/m1./s1
InChIKey
AZZMGZXNTDTSME-JUZDKLSSSA-M
Chemical Structure
2D Structure
2D structure of Cefotaxime Sodium
CAS: 64485-93-4
CID: 10695961
Formula: C16H16N5NaO7S2
MW: 477.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight477.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count12
Rotatable Bond Count8
Exact Mass477.03888450
Monoisotopic Mass477.03888450
Topological Polar Surface Area230 Ų
Heavy Atom Count31
Formal Charge0
Complexity839
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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