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Cefotaxime-d3

CAT: 0804-HY-W654101Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W654101Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cefotaxime-d3 is the deuterium labeled Cefotaxime. Cefotaxime is the β-lactamase stable cephalosporin and the third-generation cephalosporin antibiotic. Cefotaxime possesses broad-spectrum antibiotic activity against numerous Gram-positive and Gram-negative bacteria[1][2][3][4][5].
Product Name Alternative
Cefotaxim-d3; HR-756-d3
UNSPSC
12352005
Target
Antibiotic; Bacterial; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection; Others
Field of Research
Infection
Purity
98.00
Solubility
DMSO : 250 mg/mL (ultrasonic;warming)
Smiles
[H][C@@]12N(C([C@H]2NC(/C(C3=CSC(N)=N3)=N\OC([2H])([2H])[2H])=O)=O)C(C(O)=O)=C(CS1)COC(C)=O
Molecular Formula
C16H14D3N5O7S2
Molecular Weight
458.48
References & Citations
[4]E L Francke, et al. Use of cefotaxime, a beta-lactamase stable cephalosporin, in the therapy of serious infections, including those due to multiresistant organisms. Am J Med. 1981 Sep;71 (3) :435-42.|[5]Gums JG, et al. Differences between ceftriaxone and cefotaxime: microbiological inconsistencies. Ann Pharmacother. 2008 Jan;42 (1) :71-9. |[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Woodfield JC, et al. A comparison of the prophylactic efficacy of ceftriaxone and cefotaxime in abdominal surgery. Am J Surg. 2003 Jan;185 (1) :45-9. |[3]Scholz H, et al. Prospective comparison of ceftriaxone and cefotaxime for the short-term treatment of bacterial meningitis in children. Chemotherapy. 1998 Mar-Apr;44 (2) :142-7.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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