MARK-IN-4
CAT:
804-HY-112266-02
Size:
10 mg
Price:
Ask
- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
MARK-IN-4
- CAS Number: 1990492-86-8
- UNSPSC Description: MARK-IN-4 is a potent microtubule affinity regulating kinase (MARK) inhibitor with an IC50 of 1 nM. Inhibition of microtubule affinity regulating kinase (MARK) represents a potentially attractive means of arresting neurofibrillary tangle pathology in Alzheimer's disease[1].
- Target Antigen: AMPK; MARK
- Type: Reference compound
- Related Pathways: Cell Cycle/DNA Damage;Epigenetics;PI3K/Akt/mTOR
- Applications: Neuroscience-Neurodegeneration
- Field of Research: Neurological Disease
- Assay Protocol: https://www.medchemexpress.com/mark-in-4.html
- Purity: 98.99
- Solubility: DMSO : 100 mg/mL (ultrasonic)
- Smiles: O=C(C1=CC(C2=C3N=CC(C4=CN(C)N=C4)=CN3N=C2)=CS1)N[C@H]5[C@H](N)CCCC5
- Molecular Weight: 421.52
- References & Citations: [1]Sloman DL, et al. Optimization of microtubule affinity regulating kinase (MARK) inhibitors with improved physical properties. Bioorg Med Chem Lett. 2016;26(17):4362-4366.
- Shipping Conditions: Blue Ice
- Storage Conditions: -20°C (Powder, protect from light, stored under nitrogen)
- Clinical Information: No Development Reported