Serotonin

• UNSPSC Description:

  Serotonin is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin is also a catechol O-methyltransferase (COMT) inhibitor with a Ki of 44 μM.

• Target Antigen:

  5-HT Receptor; COMT; Endogenous Metabolite

• Type:

  Natural Products

• Related Pathways:

  GPCR/G Protein;Metabolic Enzyme/Protease;Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/Serotonin.html

• Purity:

  99.86

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)|H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C)

• Smiles:

  OC1=CC2=C(NC=C2CCN)C=C1

• Molecular Weight:

  176.22

• References & Citations:

  [1]Tsao D, et al. Serotonin-induced hypersensitivity via inhibition of catechol O-methyltransferase activity. Mol Pain. 2012 Apr 13;8:25.|[2]Shajib MS, et al. Interleukin 13 and serotonin: linking the immune and endocrine systems in murine models of intestinal inflammation. PLoS One. 2013 Aug 28;8(8):e72774.bioRxiv. 2024 November 03.|Curr Res Food Sci. 2024 Apr 26:8:100754.|Int J Mol Sci. 2022, 23(20), 12420.|J Exp Clin Cancer Res. 2024 Oct 10;43(1):284.|Authorea. September 19, 2022.|bioRxiv. 2023 Oct 13.|bioRxiv. 2024 November 03.|J Immunother Cancer. 2021 Jul;9(7):e002383.|Nature. 2024 Dec 18.|Res Sq. 2024 Jun 11.|Research Square Preprint. 2023 Dec 28.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, sealed storage, away from moisture)

• Clinical Information:

  Launched

• CAS Number:

  50-67-9