Docosahexaenoyl serotonin

• Product Name Alternative:

  DHA-5-HT

• UNSPSC Description:

  Docosahexaenoyl serotonin (DHA-5-HT) is an endogenous n-3 fatty acid-serotonin conjugate. Docosahexaenoyl serotonin is an inhibitor of IL-17. Docosahexaenoyl serotonin has anti-inflammatory activity[1][2].

• Target Antigen:

  Interleukin Related

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/docosahexaenoyl-serotonin.html

• Purity:

  99.0

• Solubility:

  10 mM in DMSO

• Smiles:

  CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(NCCC1=CNC2=C1C=C(O)C=C2)=O

• Molecular Weight:

  486.69

• References & Citations:

  [1]Poland M, et al. Docosahexaenoyl serotonin, an endogenously formed n-3 fatty acid-serotonin conjugate has anti-inflammatory properties by attenuating IL-23-IL-17 signaling in macrophages. Biochim Biophys Acta. 2016 Dec;1861(12 Pt A):2020-2028.|[2]Wang Y, Balvers MGJ, Hendriks HFJ, Wilpshaar T, van Heek T, Witkamp RF, Meijerink J. Docosahexaenoyl serotonin emerges as most potent inhibitor of IL-17 and CCL-20 released by blood mononuclear cells from a series of N-acyl serotonins identified in human intestinal tissue. Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Sep;1862(9):823-831.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Solution, -20°C, 2 years

• Clinical Information:

  No Development Reported

• CAS Number:

  283601-58-1