Serotonin

• Description:

  Serotonin is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin is also a catechol O-methyltransferase (COMT) inhibitor with a Ki of 44 μM.

• Product Name Alternative:

  5-Hydroxytryptamine; 5-HT

• UNSPSC:

  12352005

• Hazard Statement:

  H301

• Target:

  5-HT Receptor; COMT; Endogenous Metabolite

• Type:

  Natural Products

• Related Pathways:

  GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/Serotonin.html

• Purity:

  99.86

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  OC1=CC2=C(NC=C2CCN)C=C1

• Molecular Formula:

  C10H12N2O

• Molecular Weight:

  176.22

• Precautions:

  H301

• References & Citations:

  [1]Tsao D, et al. Serotonin-induced hypersensitivity via inhibition of catechol O-methyltransferase activity. Mol Pain. 2012 Apr 13;8:25.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, sealed storage, away from moisture)

• Scientific Category:

  Natural Products

• Clinical Information:

  Launched

• Isoform:

  Human Endogenous Metabolite; Microbial Metabolite

• Citation 01:

  BioRxiv. 2024 November 03.|bioRxiv. 2025 Oct 14.|Cell Stem Cell. 2025 May 1;32 (5) :778-794.e10.|Curr Res Food Sci. 2024 Apr 26:8:100754.|Int J Mol Sci. 2022 Oct 17;23 (20) :12420.|iScience. 2025 Jun 18;28 (7) :112931.|iScience. 2025 Nov 18.|J Exp Clin Cancer Res. 2024 Oct 10;43 (1) :284.|Neurosci Bull. 2025 Jul;41 (7) :1229-1245.|Authorea. September 19, 2022.|Behav Brain Res. 2025 May 7:115620.|Biochem Biophys Res Commun. 2025 Sep 19:785:152676.|bioRxiv. 2023 Oct 13.|bioRxiv. 2024 November 03.|bioRxiv. 2025 Sep 28.|Food Res Int. 2025 Aug:214:116675.|Immunity. 2025 Aug 12:S1074-7613 (25) 00314-0.|J Dent Sci. 2025 Apr 15.|J Immunother Cancer. 2021 Jul;9 (7) :e002383.|Nature. 2025 Jul;643 (8070) :192-200.|Res Sq. 2024 Jun 11.|Research Square Preprint. 2023 Dec 28.|SSRN. 2025 Apr 24.

• CAS Number:

  [50-67-9]